Mechanisms of Protective Immunogenicity of Microbial Vaccines of Military Medical Significance.
Abstract
Clinical studies of Q fever vaccine have been undertaken with screening of volunteers for humoral and cellular immune reactivity to specific Q fever antigens. A rapid and simplified immunofluorescent procedure has been developed for serodiagnosis of Q fever and tularemia suitable for field use. Excellent correlation exists between the results of this procedure and standard complement fixation testing for diagnosis of Q fever. Lot-to-lot variability of phase I Q fever vaccine has been assessed by in vitro lymphocyte transformation testing of immune guinea pigs. There is a consistent response between lots of vaccine by this technique and no evidence of endotoxin contamination in the vaccine. Delayed hypersensitivity skin testing of guinea pigs with Q fever antigen has revealed granulomatous changes with giant cell prominence. The immunologic basis of the granulomatous response is under analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 30, 1981
- Accession Number
- ADA140715
Entities
People
- M. S. Ascher
Organizations
- University of California, Irvine