Mutagenic Activity of Dimethylsulfoxide (DMSO) Solvent Samples from Munition Pilot Test Plant on Mammalian Cells

Abstract

Two DMSO solvent samples containing munition constituents contained a direct-acting mutagen(s). Of the two samples, DMSO recycle solvent sample had a more acute mutagenic activity than DMSO evaporator sludge sample at comparable dilution of the stock solution. The mutagenic activity in these samples was not augmented with addition of rat liver S-9. Since these samples are a mixture of several compounds, the identity of the specific compound(s) responsible for the mutagenic activity is not known.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1983
Accession Number
ADA141024

Entities

People

  • Amy Aotaki-keen
  • Thomas G. Kawakami

Organizations

  • University of California, Davis

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • California
  • Carcinogens
  • Culture Techniques
  • Dilution
  • Energy
  • Evaporators
  • Identities
  • Laboratory Procedures
  • Literature
  • Mixtures
  • Munitions
  • Mutagenicity Tests
  • Mutations
  • Toxicity
  • Toxicology

Readers

  • Environmental Engineering.
  • Oncology and Biomarker-Based Cancer Detection.
  • Toxicology/Environmental Toxicology