Organophosphate Toxicity: Genetics, Receptors, and Antidotes

Abstract

Studies were completed on the time course of the effect of DFP on brain acetylcholinesterase ACH activity. While brain ACH activity is maximally depressed only 5 minutes after administration, most behavior effects require two or more hours before the maximal effect is seen. Following a 6.33 mg/kg dose of DFP the activity of brain ACH does not return to control levels, even after 30 days. This effect is dose-dependent ad affects all brain regions equally. Behavioral studies as well as studies to demonstrate tolerance to DFP have been conducted. Pyridine Chemistry has been studied in an attempt to develop nictonic receptor agonists.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1983
Accession Number
ADA141059

Entities

People

  • Allan C. Collins

Organizations

  • University of Colorado Boulder

Tags

Communities of Interest

  • Autonomy
  • C4I

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Antidotes
  • Behavioral Genetics
  • Body Temperature
  • Body Weight
  • Brain
  • Chemical Synthesis
  • Chemistry
  • Complex Mixtures
  • Data Science
  • Genetics
  • Heart Rate
  • Information Science
  • Measurement
  • Nitriles
  • Organic Chemistry
  • Poisoning

Fields of Study

  • Medicine

Readers

  • Neurotoxicology
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology