Responses of Cholinergic and Noncholinergic Renshaw Cell Receptors After Acute and Chronic Exposure to Anticholinesterases.

Abstract

The fine structural changes in the most ventral regions of the ventral horn of spinal segment L7 have been studied in cats after single and chronic low dose exposure to diisoproylfuorophosphate (DFP). Motoneurones of the chronically treated animals show an increase in the number of lysosomes, neurofilaments, and vesicle-like structures. A large number of coated vesicles is observed within axons and axon terminals of both acute and chronically treated animals. Mohrphological evidence of axon and terminal degeneration is seen only in chronically treated animals. Degeneration is revealed by the presence of membrane-bound structures, glycogen granules, lamellar and dense lamellar bodies, increased amounts of smooth axonal endoplasmic reticulum (sAER), neurofilaments and accumulation of microtubules. Axonal degeneration in the ventral horn of L7 after chronic low dose exposure to DFP is suggested to be a retrograde process starting at the presynaptic terminals.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1983
Accession Number
ADA142398

Entities

People

  • K. C. Sikora-van Meter
  • W. G. Van Meter

Organizations

  • Iowa State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood-Brain Barrier
  • Brain
  • Cardiovascular Physiological Phenomena
  • Cells
  • Central Nervous System
  • Endoplasmic Reticulum
  • Enzyme Inhibitors
  • Materials
  • Nerve Fibers
  • Nerves
  • Nervous System
  • Neurons
  • Neurosciences
  • Peripheral Nervous System
  • Spinal Cord
  • Synapses
  • Tissues

Readers

  • Medical Imaging.
  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology