Chemical and Molecular Biological Aspects of Alkylhydrazine-Induced Carcinogenesis in Human Cells in Vitro. Revised
Abstract
The syntheses for 1,1-(methyl-14C)-dimethylhydrazine, 1,2-(methyl- 14C)-dimethylhydrazine, and the important metabolite of 1,2-dimethylhydrazine, namley, 14C-methylazoxymethanol as an acetate derivative are described. Materials for high specific activity were employed to (1) Investigate early events in carcinogenesis; (2) Study DNA modification and damage; and (3) Probe effects of anticarcinogen benzamide, on molecular perturbation of DNA by methylazoxymethanol acetate.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1984
- Accession Number
- ADA142428
Entities
People
- D. T. Witiak
Organizations
- Ohio State University