The Effects of Hyperbaric Pressure on in vitro Neural Receptors.
Abstract
In vitro preparations of the nicotinic acetylcholine receptor from rat muscle and eel electroplax were chemically and pharmacologically characterized and then subjected to compression/decompression to/from 800 psi. Pressure causes a reversible decrease in cholinergic agent binding to the receptor. This decrease is prevented if agents such as hexamethonium and diisopropylfluorophosphate are present. These studies imply that pressure effects on molecular interactions at neural receptors could account for hyperbaric neurological disorders. In addition, hyperbaric therapy could be successful in cases of toxin and organophosphorus agent intoxication. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1984
- Accession Number
- ADA142442
Entities
People
- R. F. Taylor
Organizations
- Arthur D. Little