Chemical Characterization and Toxicologic Evaluation of Airborne Mixtures. Inhalation Toxicology of Diesel Fuel Obscurant Aerosol in Sprague-Dawley Rats. Final Report. Phase 2. Repeated Exposures.
Abstract
A series of repeated exposures of rats to aerosolized diesel fuel was performed to help establish (1) indices of potential toxicity resulting from aerosol exposure and (2) the relative importance of duration of exposures, the frequence of exposures, and aerosol concentration in the induction of observed lesions. Twelve groups of animals (24 per sex in each group) were exposed to combinations of exposure frequency (1 or 3 exposures/week), exposure duration (2) or 6 hours) and aerosol concentration (expressed as the product of concentration x time for convenience, with values of 0, 8, or 12 mg h/L). Each group received 9 exposures. Body weight and food consumption were recorded on a weekly basis. Assays were performed on selected animals within 1-2 days after the last exposure or after 2 weeks without exposure. Endpoints included number and phagocytic activity of pulmonary free cells, pulmonary function tests, neurotoxicity assays, clinical chemistry, organ weights, and histopathology. Data were analyzed by analysis of variance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1982
- Accession Number
- ADA142540
Entities
People
- R. Schmoyer
- S. Lock
- W. Dalbey
Organizations
- Oak Ridge National Laboratory