Chemical Characterization and Toxicologic Evaluation of Airborne Mixtures. Diesel Fuel Smoke Particulate Dosimetry in Sprague-Dawley Rats,
Abstract
The use of decachlorobiphenyl (DCBP) as a dosimetric tracer for a diesel fuel smoke aerosol is described. DCBP added to the fuel prior to aerosolization is distributed sorely into the particle phase of the resulting smoke. DCBP is distributed uniformly throughout the aerosol particles, regardless of particle size. Determinations of DCBP in tissue extracts of rats exposed to DCBP-containing smoke were performed by purifying the extracts on activated Florisil, and subsequently analyzing them by gas/liquid chromatography with electron capture detection. The largest internal amounts of smoke tracer were found in the lungs. Animals exposed at concentration-time products (Ct) of 8 had between 2 and 4 mg smoke in their lungs, while animals exposed at Ct=12 had between 3 and 6 mg smoke in their lungs. At a given exposure duration, animals exposed at high smoke concentrations had greater levels of tracer deposited in their lungs. Tracer found in the upper respiratory tract accounted for less than 1.5 percent of the total internal dose, while that found in the digestive system accounted for approximately 30% of the total internal dose.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1983
- Accession Number
- ADA142914
Entities
People
- D. L. Manning
- J. H. Moneyhun
- M. P. Maskatinec
- R. A. Jenkins
- W. Dalbey
Organizations
- Oak Ridge National Laboratory