Dermal Sensitization Potential of Insect Repellents: Methyl N,N'-Dihexylethylenediaminemonocarbamate (CHR4), (E)-1,2,3,4-Tetrahydro-6-Methyl-1-(2-Methyl-1-Oxo-2-Butenyl) Quinoline (CHR5), and 1,2,3,4-Tetrahydro-6-Methyl-1-(3-Methyl-1-Oxo-2-Butenyl) Quinoline (CHR6).

Abstract

The insect repellents methyl N,N'dihexylethylenediaminemonocarbamate (CHR4), (E)-1,2,3,4-tetrahydro-6-methyl-1-(2-methyl-1-oxo-2-butenyl) quinoline (CHR5), and 1,2,3,4-tetrahydro-6-methyl-1-(3-methyl-1-oxo-2-butenyl) quinoline (CHR6) were tested for dermal sensitization potential using the Guinea Pig Skin Sensitization Test. The study was conducted in compliance with the Good Laboratory Practice regulations. The data collected was analyzed by the method of the U.S. Army Environmental Hygiene Agency. By this method, none of the repellents tested indicated sensitizing potential.

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Document Details

Document Type
Technical Report
Publication Date
May 20, 1984
Accession Number
ADA142925

Entities

People

  • L. J. Sauers
  • M. A. Hanes
  • T. P. Kellner

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Analytical Chemistry
  • Biological Sciences
  • Biomedical Research
  • Boiling Point
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Data Analysis
  • Hygiene
  • Insect Repellents
  • Military Research
  • Plastic Explosives
  • Propylene Glycol
  • Rodents
  • Toxicity
  • Toxicology

Fields of Study

  • Chemistry

Readers

  • Toxicology/Environmental Toxicology