Evaluation in Rhesus Monkeys of a Bivalent Live Attenuated Dengue Vaccine Containing Types 2 and 4 Viruses.

Abstract

The purpose of this study was to determine whether a bivalent (dengue-2-4) vaccine could confer immunity in rhesus monkeys against wild type virus infection. It was found that: (1) DEN-2/S-1 animals showed an anamnestic response as well as undetectable viremia after challenge with w.t. DEN-2 virus. Divalent vaccines also showed an anamnestic response after DEN-2 virus challenge. (2) DEN-4 vaccine did not elicit a measurable immune response in 6/8 animals as judged by PRNT, augmented N tests and by DEN-2 challenge experiments. An anamnestic response was observed in 2/8 animals. (3) N antibody levels of most of the vaccinated animals declined markedly on or before post vaccination day 150. (4) Viral interference among the two different vaccine serotypes could not be demonstrated.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1984
Accession Number
ADA143082

Entities

People

  • E. Kraiselburd

Organizations

  • University of Puerto Rico

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Agreements
  • Animals
  • Antibodies
  • Biomedical Research
  • Control
  • Infection
  • Laboratory Animals
  • Monkeys
  • Puerto Rico
  • Rhesus Monkeys
  • Technical Information Centers
  • Test And Evaluation
  • Two Dimensional
  • Vaccination
  • Vaccines
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Immunology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology