Dermal Penetration and Distribution of 14C-Labeled 1-(3-Cyclohexen-1-YL-Carbonyl) Piperidine, AI3-35765.
Abstract
The candidate insect repellent 1-(3-cyclohexen-1-yl-carbonyl) piperidine, AI3-35765, was assessed for skin absorption potential in rats and dogs by monitoring radiocarbon in excreta for 7 days following a single application. In both species, absorption occurred primarily in the first 24 hours and measured 32 percent of the applied dose in rats and 21 percent in dogs through 7 days. No marked bioaccumulation in animal tissue specimens was noted at necropsy by this route. Absorption in man should be less than 12 percent of a topical dose.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1984
- Accession Number
- ADA143281
Entities
People
- H. L. Snodgrass Jr.
Organizations
- United States Army Medical Command