Correlation between Plasma Fibronectin Level and Mortality Following Experimental Rate Heat Stress,

Abstract

Reticuloendothelial system (RES) clearance function correlates with the mortality rate associated with stresses which can induce shock. Likewise, mortality rate after experimental rat heat stress (ERHS) is altered by modulation of RES function. Since plasma fibronectin (PF) mediates in vivo phagocytosis by the RES, the relationship between mean plasma fibronectin level (MPFL) and mortality after ERHS was examined. A comparison of MPFLs prior to ERHS revealed that rats which ultimately comprised the survival group had a MPFL (269.0 + 11.2 microgram/ml) which exceeded the value determined for the non-survivors (252.9 + or - 11.9 microgram/ml). Both groups had elevated MPFLs, up to 12 h following ERHS. However, after this time, MPFL began to decline. The decline was more severe for the non-survivors, with MPFLs at 15, 18, and 24 h, significantly (p<0.01) lower than the values for the survival group.

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Document Details

Document Type
Technical Report
Publication Date
Jul 07, 1984
Accession Number
ADA143383

Entities

People

  • D. A. Dubose
  • J. Mccreary
  • L. Sowders

Organizations

  • United States Army Research Institute of Environmental Medicine

Tags

DTIC Thesaurus Topics

  • Analysis Of Variance
  • Blood
  • Blood Proteins
  • Clearances
  • Data Science
  • Hemorrhagic Shock
  • Information Science
  • Jugular Vein
  • Materials
  • Military Research
  • Resistance
  • Reticuloendothelial System
  • Security
  • Statistical Analysis
  • Time Intervals
  • Veins
  • Vena Cava

Readers

  • Immunology and Pathology
  • Mathematics or Statistics
  • Regression Analysis.