Fluid Replacement during Hypothermia,
Abstract
Hypothermia produces acidoses, depressed cardiac function, hypovolemia and hypotension. This study was designed to examine the cardiovascular dynamics involved with restoration of the hypovolemia before rewarming. Mixed breed splenectomized adult dogs (n=16) were anesthetized with pentobarbital and cooled to a right atrial temperature of 25 deg C at a rate of 3 deg C/Hr. The animals were maintained at 25 deg C for 6 hours and rewarmed at 3 deg C/Hr. One group (1) was given no fluid, one group (2) was given saline (20% of plasma volume infused in 10 min.) two hours after reaching 25 deg C and one group (3) received saline just prior to rewarming. The hematocrit was elevated in all groups (P<or= 0.05) upon cooling, but did not differ between groups even after saline was given. Cardiac output (CO) at 25 deg C was 35% of precooled values. The second group increased their CO by 15% with fluid and this CO was maintained higher than groups 1 or 3 for the next four hours. Plasma volume, heart rate, and cardiac contractility returned to control levels upon rewarming, but CO remained low (<or= 10%). The level of CO at the start of rewarming did not affect the final level of CO.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 02, 1984
- Accession Number
- ADA143807
Entities
People
- C. Murray
- D. E. Roberts
- D. Kerr
- J. G. Barr
- R. Harris
Organizations
- United States Army Research Institute of Environmental Medicine