Mechanisms of Rapid Nonspecific Resistance Induced by Immunomodulators: Delineation Using Selective Depletion of Cells.

Abstract

We have analyzed the effects of 89Sr treatment on various effector cell populations, including circulating monocytes and PMN, resident peritoneal M0, and splenic NK and NC cells. The short term 89Sr regimen is now sufficiently characterized to be useful in predicting which nonspecific effector cell populations are important in natural and immunomodulator-enhanced host resistance. Within a week after 89Sr treatment, there is a profound decrease in the numbers of all circulating white blood cells, no marked change in resident peritoneal M0, a significant decrease in spontaneous as well as interferon-inducible NK.

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Document Details

Document Type
Technical Report
Publication Date
Jul 30, 1984
Accession Number
ADA144101

Entities

People

  • A. Volkman
  • P. S. Morahan

Tags

DTIC Thesaurus Topics

  • Bacterial Infections
  • Blood
  • Blood Cells
  • Bone Marrow
  • Cells
  • Infection
  • Leukocytes
  • Listeria Monocytogenes
  • Listeriosis
  • Lymphatic System
  • Lymphocytes
  • Macrophages
  • Microbiology
  • Microorganisms
  • Monocytes
  • Proteins
  • Tissues

Fields of Study

  • Medicine

Readers

  • Immunology
  • Immunology and Pathology
  • Mathematics or Statistics