Topical Hazard Evaluation Program of Hexahydro-1-((2-Methylcyclohexyl) Carbonyl))-1-H-Azepine (AI3-35770), US Department of Agriculture Candidate Insect Repellent.

Abstract

All sample batches of hexahydro-(2-methylcyclohexyl) carbonyl)-1-H-azepine, Candidate Insect Repellent AI3-35770, produced moderate to severe primary irritation of the intact skin and of the skin surrounding an abrasion. This lesion was characterized by a palpable thickening of the skin, hyperkeratosis, with eventual sloughing of the application site. Ethanol solutions of these chemicals were moderately irritating to the intact skin, and did not produce as severe a response as the technical chemicals. Washing the skin with soap and water, 6 hours after application, of either the technical chemical or ethanol solutions did not reduce the severity of dermal irritation.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1984
Accession Number
ADA144424

Entities

People

  • J. G. Harvey Jr
  • J. V. Wade

Organizations

  • United States Army Medical Command

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alcohols
  • Animals
  • Chemical Synthesis
  • Eye
  • Health
  • Health Services
  • Hygiene
  • Insect Repellents
  • Laboratory Animals
  • Lagomorphs
  • Pest Control
  • Physical Properties
  • Public Health
  • Rodents
  • Skin Diseases
  • Toxicology

Readers

  • Environmental Engineering.
  • Toxicology/Environmental Toxicology