Toxicology of Mixed Distillate and High-Energy Synthetic Fuels
Abstract
In joint research to assess the hazard of exposure to hydrocarbon aircraft and missile fuels. the United States Air Force (USAF) and United States Navy (USN) have performed long-term inhalation exposures to numerous military fuel vapors. From these studies, a general picture of the toxic response to the hydrocarbon fuels is evolving. Male rats sacrificed immediately after continuous 90-day exposures display renal proximal tubule degeneration and multifocal dilation near the corticomedullary junction. caused by plugs of necrotic cell debris. At terminal sacrifice, 19 months postexposure, male rat kidneys exhibit marked medullary mineralized casts. multifocal and diffuse hyperplasia of pelvic urothelium, and advanced tubular degeneration compatible with "old-rat nephropathy." After one-year intermittent exposures. extensive proximal tubulardegeneration is not observed; however, at terminal sacrifice, there are significant numbers of renal tumors in male rats. Neither toxic nephropathy nor renal tumors were found in female rats and other species examined. Female mice exposed to hydrocarbon fuels exhibited mild. reversible hepatocellular fatty changes immediately postexposure; however. these lesions were absent at the 24-month sacrifice. The mechanisms of dose-dependent, hydrocarbon-induced male rat nephropathy and renal tumors. and fatty vacuoles in female mice livers are not known.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1984
- Accession Number
- ADA144873
Entities
People
- David E. Uddin
- Michael G. Macnaughton
Organizations
- Air Force Research Laboratory