Immunochemistry of Rat Lung Tumorigenesis
Abstract
Changes in cell mediated immunity have been identified in relation to tumorigenesis. Most chemical carcinogens were found to be immunosuppressive. Cytogenetic changes and impaired DNA repair-synthesis were also found to be associated in chemical carcinogenesis. Measurement of temporal variability of immunologic, cytogenetic and DNA repair changes in relation to exposure to chemical carcinogens and throughout initiation and progression of lung cancer in an animal model is the subject of this research project. The first phase of this investigation includes the in vitro measurement of cellular immune response as well as sister chromatid exchange and DNA replication and repair synthesis in spleen, thymus and blood lymphocytes in control rats. This project was initiated in November of 1980; therefore, this annual report reflects only 8 months of work. It is projected that Phase I be concluded by the end of 1981. This will be followed by Phase II which will include the measurement of cellular immune parameters, sister chromatid exchange and DNA replication and repair synthesis in spleen, thymus and blood lymphocytes throughout tumorigenesis in rats intratracheally exposed to 3-methylcholanthrene.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1981
- Accession Number
- ADA145010
Entities
People
- Hoda A. Guirgis
Organizations
- University of California, Irvine