Jet Lag Prevention: Physiological Mechanisms and Pharmacological Therapy.
Abstract
This research program was concerned with the physiological mechanisms that underlie the phenomenon of jet-lag and was aimed at developing therapeutic techniques to minimize the performance and physiological deficits that occur in rapid transmeridian air travel. During the course of this project, the circadian pacemaker responsible for the timing of the daily rest-activity was identified in the brain of the diurnal primate, the squirrel monkey (Saimiri sciureus). The suprachiasmatic nuclei were also identified in the human brain. A number of other significant advances included: developing a model of the circadian sleep-wake cycle, characterizing how phase shifts of the light-dark cycle reset the timing of the sleep-wake cycle, and identifying pharmacological agents which can phase-reset the circadian system.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 31, 1984
- Accession Number
- ADA145444
Entities
People
- M. C. Moore-ede
Organizations
- Harvard Medical School