Molecular Interactions of High Energy Fuels and Jet Fuels with Oncogenic Viruses and Endogenous Viruses.
Abstract
The objectives of this research were to develop rapid in-vitro assays, to evaluate the carcinogenic potential of chemicals used by the U.S. Air Force. Snyder-Theilen Feline Sarcoma Virus (ST-FeSV), quantitatively transforms human skin fibroblasts following second order kinetics. These studies were performed in order to determine whether chemicals altered ST-FeSV transformation in a predictable manner and to correlate the alteration with the carcinogenic or non-carcinogenic activity of the test chemical. The results, to date, show diverse carcinogens classed as: aromatic amines, polycyclic hydrocarbons, aminofluorenes, hydrazines, asbestos and mycotoxins inhibited virus transformation when virus infected cells (2 hours post-infection) were exposed to test chemical, while non-carcinogenic chemicals had no significant effect on transformation. Triton X-100, acetone, petroleum and shale oil derived JP5; RJ5 and diesel fuel, marine, demonstrated non-carcinogenic activity while formalin demonstrated carcinogenic activity. Experiments designed to show the specificity of the antagonistic effect of known carcinogens are reported.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1984
- Accession Number
- ADA145484
Entities
People
- J. R. Blakeslee Jr
Organizations
- Ohio State University