Mechanisms of Oxygen Toxicity and Methods of Protection.
Abstract
The mechanism by which oxygen causes convulsions is not clear. Although man biochemical changes in brain have been reported to occur as a result of oxygen exposure, these changes are not necessarily the cause of oxygen-induced convulsions. From in vivo studies in mice, inhibition of brain energy metabolism was not found. Furthermore, although oxygen caused an increased oxidation of pyridine nucleotides, the decrease in both NADPH and NADH in cerebral cortex was not-related to the susceptibility fo mice to oxygen convulsions. GABA in brain cortex was decreased by oxygen, however, this decrease did not influence the susceptibility of mice to oxygen convulsions. The most effective CNS protectants seem to be those agents containing a disulfide bridge in their molecular structure, and which can be reduced to thiols. Since thiols are good free radical scavengers, free radicals may be the initial event in provoking the insult to produce oxygen convulsions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 13, 1984
- Accession Number
- ADA145830
Entities
People
- M. D. Faiman
Organizations
- University of Kansas