A Biodegradable Proteolipid Bone Repair Composite,
Abstract
A synthetic proteolipid was combined with a biodegradable copolymer (50:50) poly(L)-lactide co-glycolide) and inserted into defects prepared in the tibias of rats. At 3, 7, 14, 21, 28, and 42 days, animals were sacrificed and the implant sites were prepared for histomorphometric evaluation. Control defects, defects filled with copolymer alone, and defects filled with copolymer combined with proteolipid were analyzed with a Zeiss Image Analysis System with Osteoplan version 4.1. A two-way analysis of variance revealed more reparative bony elements in the defects filled with copolymer-proteolipid at an earlier period of time than either the copolymer alone or control sites. The copolymer-proteolipid implant amy provide to be an alternative to the agents commonly used for osseous repair.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 26, 1984
- Accession Number
- ADA146141
Entities
People
- J. O. Hollinger
- J. P. Schmitz
Organizations
- United States Army Institute of Surgical Research