Effects of Hallucinogenic Agents on Nerve and Muscle.
Abstract
The original problem was to characterize the effects of hallucinogens, Ketamine and ditran, on endplate current (e.p.c.) parameters and to compare these with those of PCP. The model being used to establish uniform characteristics of these agents at the neuromuscular junction might be useful in understanding hallucinogenic drug action at other sites, particularly the brain. Ultimately, we planned to test methods of reversal of these effects at the neuromuscular junction which might be therapeutically useful in reversing hallucinogenic manifestations clinically. In addition, we studied and characterized the interaction of several other classes of drugs (particularly irreversable acetylcholinesterase inhibitors) with the neuromuscular junction.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 1983
- Accession Number
- ADA146306
Entities
People
- E. G. Henderson
Organizations
- University of Connecticut Health Center