Interaction between Lung Mechanics and Gas Exchange by Low Volume High Frequency Pulmonary Ventilation in Patients with Respiratory Failure.
Abstract
Research progress has been made toward two goals in the first contract year, patient studies and model studies. In the patient studies we investigated the relationship between airway pressure and lung volume during high frequency low tidal volume ventilation (HFV). Patients requiring mechanical ventilatory support for treatment of respiratory insufficiency were studied by imposing rapid (1-10 Hz) oscillations with low tidal volumes (50-150 m1) at a constant mean airway pressure of 5 cm H2O. In the model studies the pressure drop during sinusoidal mean flows in a four generation network of rigid, uniform diameter, symmetrically branching tubes was studied. The data obtained were analyzed via a process of Fourier decomposition. The results showed that the pressure signals consist mainly of a dominant component at the excitation frequency (fundamental) and a first harmonic of smaller magnitude. We found the magnitude and phase of the fundamental to correlate closely with classical predictions as long as the parameter was less than 200.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 22, 1983
- Accession Number
- ADA146604
Entities
People
- A. F. Saari
- A. S. Slutsky
- J. Lehr
- J. M. Drazen
- J. Solway
Organizations
- Brigham and Women's Hospital