An Atropinized Heat-Stressed Rat Model: Dose Response Effects and Pharmacokinetics,
Abstract
Atropine and other anticholinergic drugs are widely used in common medications such as antihistamines and tranquilizers as well as in the treatment of organophosphate poisoning. Since atropine administration inhibits thermoregulatory efficiency in the heat in both man and the rat by reducing sweating and salivation respectively, we sought to quantitate the effects of atropine in our rat heatstroke model. Using this sedentary, heat-stressed rat model, we have determined that atropine increases the heating rate up to 3h after drug administration and that this elevation in heating rate is dose-dependent over the range from 10-1000ug/kg. The clinically used human dosages of atropine fall well within this range.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1984
- Accession Number
- ADA146851
Entities
People
- C. B. Matthew
- R. P. Francesconi
- R. W. Hubbard
Organizations
- United States Army Research Institute of Environmental Medicine