An Investigation of Membrane-Encapsulated Trypanocides.
Abstract
This progress report describes our research in studying the in vivo properties of liposomes as a potential drug carrier for trypanocidal agents. The report contains four sections. The first section describes a new method to load high levels of In-111 to liposomes, using 8-hydroxyquindine and/or acetylacetone. The second section is a report of the finding of a large volume of distribution of sphingomyelin/cholesterol small unilamellar liposomes and their ability to get out of the vascular bed of a mouse. The third section discusses the determination of the in vivo rate of release of liposome-entrapped In-111 in the liver and the influence of the liposomal size on the release. The fourth section describes the effect of lipid dose on the rate of the elimination of the long-lived sphingomyelin/cholesterol small unilamellar liposomes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 02, 1982
- Accession Number
- ADA146853
Entities
People
- K. J. Hawang
Organizations
- University of Washington