Dermal Penetration and Distribution of 14C-Labeled Ethylene Diamine Dinitrate. Phase 2, April - July 1984

Abstract

Ethylene diamine dinitrate (EDDN) is an explosives component having potential for occupational skin exposure. The dermal absorption and resulting bodily distribution was assessed in rats and dogs. In both species, less than 1 percent of the applied C14-labeled dose was absorbed as measured by radioactivity appearing in excreta through 7 days. About 1.5 percent remained in animal carcasses at necropsy. Retention was not organ specific. In man, less than 2 percent absorption is expected following a single dermal exposure. No significant tissue retention is anticipated. Originator-supplied keywords include: Intravenous, Penetration, Percutaneous, Radiolabeled, and Topical.

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Document Details

Document Type
Technical Report
Publication Date
Oct 31, 1984
Accession Number
ADA147361

Entities

People

  • H. L. Snodgrass Jr.

Organizations

  • United States Army Medical Command

Tags

DTIC Thesaurus Topics

  • Absorption
  • Adrenal Glands
  • Alkenes
  • Bile
  • Blood
  • Bone Marrow
  • Chemistry
  • Endocrine Glands
  • Ethylenes
  • Explosives
  • Health Services
  • Kinetics
  • Medical Personnel
  • New England
  • Plastic Explosives
  • United States
  • Veins

Readers

  • Organic Chemistry
  • Toxicology/Environmental Toxicology