Neurochemical Mechanisms Mediating Recovery of Function.
Abstract
We have completed studies on the changes in behavior which occur following damage to the basal forebrain cholinergic (Ch) system in the mammalian central nervous system. Sodium dependent high affinity uptake of the Ch precursor choline was used as an indication of activity in the Ch neuronal system. This measure is specific for the Ch system and is increased following increased firing and decreased following decreased firing of these neurons. There was a significant increase in choline uptake in the hippocampus following performance on a T-maze and the radial arm maze. This laboratory has previously shown that the performance of these behaviors typically requires an intact hippocampal Ch system. In contrast, the Ch system afferent to the neocortex was not activated during the performance of these tasks. Presently, experiments have been designed using various pharmaco-therapies in an attempt to produce a significant recovery of both biochemical and behavioral indices.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1984
- Accession Number
- ADA147577
Entities
People
- D. Olton
- G. Wenk
- Z. Annau
Organizations
- Johns Hopkins University