Comparative Biochemistry and Metabolism: Part 2. Naphthalene Lung Toxicity
Abstract
Earlier studies have shown that the volatile aromatic hydrocarbon, naphthalene, produces a highly selective lesion of the pulmonary bronchiolar epithelium in mice. This lesion appears to depend upon the cytochrome P450- mediated metabolism of the parent compound and glutathione is important in modulating the cytotoxicity. Although an excellent correlation was noted between the formation and covalent binding of highly reactive naphthalene metabolites in the target tissue with the extent and severity of the pulmonary lesion, additional studies suggested that the levels of covalently bound metabolite found in a particular tissue in vivo did not necessarily reflect the rate at which reactive metabolites were formed in situ within that tissue. Indeed, studies conducted during the current contract year have demonstrated that naphthalene oxide formed intracellularly is capable of effluxing from intact hepatocytes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 14, 1984
- Accession Number
- ADA147873
Entities
People
- A. R. Buckpitt
- P. Richieri
Organizations
- University of California, Irvine