Cellular Mechanisms of Central Nervous Modulation.
Abstract
A critical factor in our analysis of the mechanism of ionic homeostasis of the brain microenvironment, and its modulation by neurotransmitters, is the precise localization of the insect blood-brain barrier system. This system limits the movements of water-soluble ions and small molecules between the blood and the neuronal surfaces, as has been demonstrated in electrophysiological experiments. It has been supposed to be located in the perineurium since extracellular tracers (peroxidase, microperoxidase and ionic lanthanum) permeate the neural lamella, but are unable to penetrate beneath the superficial layer of neuroglia. The tracers are capable of only limited entry into the clefts between the perineurial cells, which is suggested to be due to the intercellular junctional complexes, notably tight junctions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 1981
- Accession Number
- ADA147875
Entities
People
- J. E. Treherne
Organizations
- University of Cambridge