Cellular Mechanisms of Central Nervous Modulation

Abstract

In a previous report, an account was given of a technique for selective disruption of cockroach neuroglia using ethidium bromide as a glial toxin. This compound (which binds to both DNA and RNA) disrupts the glial nuclei in central nervous connectives but does not affect axons (whose nuclei are contained in the ganglia). As described in the previous report, we have found that there is a rapid and ordered repair of the peripheral glial elements following selective disruption. A consistent feature of the early stages of glial damage is the prominent involvement of granule-containing cells which were never seen in control preparations. It was suggested that the granule-containing cells, which share a number of cytological features with haemocytes play an integral part in glial repair.

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Document Details

Document Type
Technical Report
Publication Date
Apr 30, 1984
Accession Number
ADA147880

Entities

People

  • J. E. Treherne

Organizations

  • University of Cambridge

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood-Brain Barrier
  • Boundaries
  • Brain
  • Cells
  • Central Nervous System
  • Electrical Properties
  • Electrons
  • Elements
  • Integrals
  • Microparticles
  • Microspheres
  • Modulation
  • Nervous System
  • Neuroglia
  • Potassium

Fields of Study

  • Biology

Readers

  • Neuroscience
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.