The Mechanism of Interaction of Oximes with the Muscarinic-Cholinergic Complex in the Central Nervous System

Abstract

The purpose of the studies described in the present report was to explore the mode of interaction between oximes and acetylcholine (ACh) muscarinic receptors in the brain. A better understanding of the mechanism of these interactions could help to improve the protection of oxime-muscarinic antagonist mixtures from organophosphate poisoning. In order to achieve these goals, we employed methods based on measurements of the binding of the radiolabeled muscarinic antagonist (3H)-4NMPB. The methods employed included both direct binding studies and competition experiments between labeled and unlabeled ligands. The effects of HGG bispyridinium oximes on the binding parameters of muscarinic agonists and antagonists were investigated.

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Document Details

Document Type
Technical Report
Publication Date
Nov 03, 1983
Accession Number
ADA148398

Entities

People

  • M. Sokolovsky

Organizations

  • Tel Aviv University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alkynes
  • Animal Structures
  • Brain
  • Brain Stem
  • Carrier Proteins
  • Central Nervous System
  • Cerebral Cortex
  • Inhibition
  • Inhibitors
  • Materials
  • Measurement
  • Nervous System
  • Nucleotides
  • Poisoning
  • Recognition
  • Rodents
  • Transition Metals

Readers

  • Molecular and Cellular Biochemistry
  • Neurotoxicology