Research and Development of Wound Dressing in Maxillofacial Trauma.
Abstract
Because of the natural molecular weight distribution of poly-L-(-)lactide polymerization, batches can be blended with viscosities as disparate as R.S.v. = 1.2 + or - 0.6 dl/g. Fabrics are prepared by spraying a solution of polymer and drug. Powders are prepared by grinding a cast film of polymer and drug with dry ice. Materials were characterized by drug content and timed release, and by SEM and EDAX (energy dispersive analysis of X-rays). Povidone-iodine fabrics were prepared from 20% to 75% drug. With less drug the fabric was more fibrous, but drug release was less. A 40% drug fabric was chosen for further testing. EDAX of these fabrics showed less iodine on the surface than in the total fabric. Anesthetic fabrics were prepared with benzocaine, bupivacaine-HCl, etidocaine-HCl, and lidocaine base, hydrochloride, and hydrosulfate. Generally the base form of the anesthetics deliver drug in a more continuous manner than the salt forms, and etidocaine-HCl release is more continuous than bupivacaine-HCl release.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 23, 1982
- Accession Number
- ADA148548
Entities
People
- D. E. Creeden
- D. L. Williams
- J. H. Kerrigan
- S. A. Odell