Immunomodulation with Synthetic Molecules: Mechanisms of Actions and Effects on Macrophages.
Abstract
Immunoenhancing drugs are under study both for their general effects on host immunity and their effects on immune interactions with microbial infections. These studies focused preferentially on defined synthetic single molecules, especially synthesized natural biological molecules or their active fragments. We studied the mechanism of muramyl dipeptide in inducing hyporesponsiveness of spleen cells and hyperresponsiveness of lymph node cells to mitogens defining the cell populations and mediators involved in these effects. In another study, murine macrophages from different anatomic compartments were compared for their fungicidal activity in different in vitro systems. Subsequently, the effect of a lipoidal amine immunomodulator on alveolar macrophage fungicidal activity was examined. The mechanism of immunological activation of polymorphonuclear neutrophils for fungicidal activity was studied with respect to the oxidative mechanisms involved.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1984
- Accession Number
- ADA148592
Entities
People
- C. J. Morrison
- D. A. Stevens
- E. Brummer
Organizations
- Institute for Medical Research