Altitude Exposure and the Role of Hypoxia and Arginine Vasopressin in Cerebral Fluid Dynamics.

Abstract

Through exposure of rabbits (10) to barometric pressures equivalent to that encountered at 18,000 ft for 6-8 hours, we found no increase in water content of various parts of the brain (temporal, parietal, frontal cortices; thalamus, midbrain, hindbrain, cerebellum). We have found that the cerebrospinal fluid (CSF) pressure significantly increases when rabbits are exposed to hypoxia. We conclude that the initial change in CSF dynamics with hypoxia is an increase in CSF pressure. At present we do not know if this increase is due to an increase in CSF production and/or a decrease in clearance of CSF. The role of arginine vasopressin in this process is under study. Originator-supplied keywords include: Cerebroventricular cannulation.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1981
Accession Number
ADA148643

Entities

People

  • D. L. Tolbert
  • L. C. Senay Jr.

Organizations

  • Saint Louis University

Tags

DTIC Thesaurus Topics

  • Altitude
  • Barometric Pressure
  • Blood
  • Body Fluid Compartments
  • Body Fluids
  • Body Water
  • Brain
  • Cells
  • Cellular Structures
  • Cerebral Cortex
  • Choroid Plexus
  • Fluid Dynamics
  • High Altitude
  • Hormones
  • Hypobaric Chambers
  • Laboratory Animals
  • Medical Personnel

Readers

  • Cardiovascular Physiology
  • Neuroscience