Altitude Exposure and the Role of Hypoxia and Arginine Vasopressin in Cerebral Fluid Dynamics.
Abstract
Through exposure of rabbits (V=10) to barometric pressures equivalent to that encountered at 18,000 ft for 6-8 hr, we found no increase in water content of various parts of the brain (temporal, parietal, frontal cortices; dien cephalon, mid-brain, hindbrain, cerebellum). Repeated exposure of rabbits (N=57) to hypoxia equivalent to 8,000 to 16,000 ft generally lead to an increase in CSF pressure. However, we found no influence of hypoxia upon CSF arginine vasopressin contents. When injected into the lateral ventricles of rabbits, arginine vasopressin, norepinephrine, prostaglandin E2 and prostaglandin F 1 alpha did not influence CSF pressures. Angiotensin II generally caused an increase in CSF pressure while saralasin, an AII blocker generally caused a decrease in CSF pressure when given by itself and prevented a rise in CSF pressure if given before AII. Injection of acetazolamide ito the lateral ventricles did not consistently alter CSF pressures but when given systematically, acetazolamide caused a decreae in CSF pressure in two thirds of the treated animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 31, 1983
- Accession Number
- ADA148644
Entities
People
- D. L. Tolbert
- L. C. Senay Jr.
Organizations
- Saint Louis University