Synthesis of New Prophylactic Antiradiation Drugs.
Abstract
S series of N-(3-aryl-1-adamantanemethyl)-alpha-mercaptoacetamidines and derivatives was synthesized. A number of 3-aryl-1-adamantanemethylamines B were synthesized first. These amines would become part of the N-substituent of the amidine function, R'NH-C(=NH)-CH2SY. The specific alpha-mercaptoacetamidines and derivatives, which were prepared, were those in which R=CH3, and SY is S2O3(-) (Bunte Salt), SPO3(-2) and S-S(disulfide); R=OCH3, and SY is SH,S-S(disulfide), SPO3(-2); R=F, and SY is SH, S-S(disulfide), SPO3(-2); as well as R=SCH3, where SY is S2O3(-) (Bunte Salt), or SPO3(-2). Of the 10 compounds sent to Walter Reed Army Institute for Research, 6 were evaluated for radiation protective potency in mice. The compounds showed some protective activity but did not show unusual promise, in part due to their relatively high toxicity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1982
- Accession Number
- ADA148648
Entities
People
- I. Handa
- L. Bauer
Organizations
- University of Illinois Urbana–Champaign