Synthesis of New Prophylactic Antiradiation Drugs.
Abstract
This report is divided into four (4) major sections. Each section addresses a phase of the syntheses of adamantyl aryl alkylamines where the amine is incorported into an N-substituted 2-mercaptoacetamidine, or a derivative of the sulfide function. The first part describes the efforts in the 1-aryl-3-adamantyl-methylamine series where the aryl group is 2-thienyl. The next section is devoted to the practical approaches to the synthesis of 1-aryl-2-adamantylalkyl-amines. The work culminates in the preparation of the first member, namely, 1-phenyl-2-adamantylmethylamine. The third section describes some preliminary work on the preparation of 1-aryl-4-adamantylalkylamines. And, the last section reports the synthesis of 4-(1-adamantyl)benzylamines and its conversion to the disulfide based on N-(4-(1-adamantyl)benzyl)-2-mercaptoacetamidine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1983
- Accession Number
- ADA148649
Entities
People
- L. Bauer
Organizations
- University of Illinois Urbana–Champaign