The Use of ATP-MgCl2 in the Treatment of Injury and Shock.
Abstract
In normal as well as hypovolemic awake dogs, cardiac output can be increased significantly by infusion of ATP-MgCl2 intravenously at rates of 0.5-2.5mg/kg/min. The higher doses of ATP-MgCl2 may have detrimental hemodynamic effects, however, such effects are immediately reversible by ceasing ATP-MgCl2 infusion. Moreover, the deleterious hemodynamic effects of very high doses of ATP-MgCl2 can be markedly ameliorated by atropine. Infusion of ATP-MgCl2 did not affect hepatic or renal function, myocardium or blood chemistry after infusion or even after a prolonged period of time. Infusion of even massive doses of ATP-MgCl2 have no ill effects on the survival of dogs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 31, 1982
- Accession Number
- ADA148650
Entities
People
- A. E. Baue
- I. H. Chaudry
Organizations
- Yale University