Inhalation Toxicity of Manganese Dioxide and a Magnesium Oxide-Manganese Dioxide Mixture.
Abstract
This report describes: (1) The development, characterization and use of a fluidizing bed aerosol generator; (2) Characterization of the mass and particle size distribution of aerosolized manganese dioxide (MnO2) in 1.4 cu m inhalation chambers; and (3) The results of a range-finding inhalation toxicity study of rats exposed to manganese dioxide dust. The major biologic response observed in the range-finding study was the suggestion of long-term pulmonary fibrosis. Recommendations of doses and biologic endpoints for a subchronic study are made.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1984
- Accession Number
- ADA148868
Entities
People
- R. N. Shiotsuka
Organizations
- Brookhaven National Laboratory