Army Drug Development Program. Phase 1. Clinical Testing

Abstract

Studies of WR 180,409 H3PO4, a Pyridinemethanol with all subjects developed mild gastrointestinal symptoms after receiving 750 mg of the drug orally. WR 171,669, a phenanthrene methanol with demonstrated activity against chloroquine resistant P. Falciparum malaria, was studied in a single dose, double-blind, rising dose schedule in 28 subjects. In a study of the pharmacokinetics of WR 229, 870 (Sodium Stibogluconate Injection, BP) a single intravenous dose of 600 mg of Pentostam was given to eight subjects. No acute intolerance developed. In previous studies of WR 194,965 H3PO4 (an antimalarial of the Mannich base class), the top tolerated single dose in man was found to be less than the dose that cured 100% of Aotus monkeys infected with falciparum malaria.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1981
Accession Number
ADA148919

Entities

People

  • John A. Johnson

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DTIC Thesaurus Topics

  • Body Weight
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Digestive System Processes
  • Drug Therapy
  • Health Services
  • Leukocytes
  • Liquid Chromatography
  • Lymphocytes
  • Medical Personnel
  • Pain
  • Therapy

Fields of Study

  • Biology
  • Medicine
  • Physics

Readers

  • Cardiovascular Physiology
  • Clinical Trial Research.
  • Parasitology and Pharmacology of Malaria.