Blood Substitutes: Effects on Drug Pharmacokinetics.
Abstract
The effect of exchange transfusion with Fluosol DA 20% (FDA) or stroma-free hemoglobin (SFH) on the pharmacokinetics of penicillin and diazepam and on the effectiveness of penicillin therapy of pneumococcal infection in rats was determined. FDA prolongs the half-life of penicillin and does not alter the pharmacokinetics of diazepam. SFH increases the volume of distribution of both penicillin and diazepam and increases the half-life of diazepam. Penicillin only suppresses pneumococcal infection in FDA transfused rats but cures pneumococcal infection in SFH transfused rats.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1982
- Accession Number
- ADA148928
Entities
People
- G. R. Hodges
Organizations
- University of Kansas Medical Center