Preliminary Assessment of Relative Toxicity and Mutagenic Potential of 1 Nitroso-3,5-Dinitro-1,3,5-Triazacyclohexane (Mononitroso-RDX)

Abstract

The munitions component, 1-nitroso-3, 5-dinitro-1,3,5- triazacyclohexane (Mononitroso-RDX), was assessed for its relative irritant, skin sensitization, and mutagenicity potential. It showed no potential for eye or skin irritation in rabbits following a single application. It did not prove to be a skin sensitizer to guinea pigs. Mononitroso-RDX showed positive mutagenic activity in three of four in vitro bioassays. This finding, in addition to its implicating chemical structure, would earmark the chemical as a suspect mutagen and/or carcinogen. Further testing is recommended to establish human risk. Interim protection and monitoring of operational personnel is also recommended until mutagenic/toxicological risks are resolved.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1984
Accession Number
ADA149351

Entities

People

  • H. L. Snodgrass Jr.

Organizations

  • United States Army Medical Command

Tags

DTIC Thesaurus Topics

  • Animals
  • Cells
  • Chromosome Aberrations
  • Epithelial Cells
  • Genetics
  • Genotoxicity
  • Health Services
  • Lagomorphs
  • Materials
  • Medical Personnel
  • Munitions
  • Mutagenicity Tests
  • Neoplasms
  • Nitroso Compounds
  • Rodents
  • Toxicity
  • United States

Fields of Study

  • Environmental science

Readers

  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Toxicology/Environmental Toxicology