Research and Development of Wound Dressing in Maxillofacial Trauma.
Abstract
During the contract period three batches of poly-L(-)lactide were prepared and blended with material in stock to give 1,904 grams of polymer with an R.S.V. of 1.14 dl/g. About 1,400 grams remain. Polymer was used to prepare three basic formulations, non-woven fabrics, powders, and microcapsules, of local anesthetic agents, antiseptics, and antibiotics. These formulations were characterized by scanning electron microscopy, in vitro drug release rate, and in vivo efficacy. Efficacy evaluation of sustained-release anesthetic fabrics was concluded. Using a rat sciatic nerve block model etidocaine fabric was shown to induce good local anesthesia. Three antiseptics, povidone iodine, (PVP-I2), nitrofurazone, chlorhexidine diphosphanilate were studied. Two antibiotics, ampicillin and clindamycin, have been utilized. Fabrics prepared from ampicillian (trihydrate and anhydrous) provided slow drug release in all test systems. Clindamycin fabrics and powders have been prepared and tested. Originator furnished keywords include: biological and medical sciences, antiinfectives, antiseptics, antibiotics, pharmacology, polymers, polylactide, encapsulating, powders (particles), fabrics, sustained-release.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 11, 1984
- Accession Number
- ADA150034
Entities
People
- D. E. Creeden
- D. L. Williams
- J. H. Kerrigan
- M. H. Gay
- W. A. Nucefora