Chemical Characterization and Toxicologic Evaluation of Airborne Mixtures. Inhalation Toxicology of Diesel Fuel Obscurant Aerosol in Sprague-Dawley Rats. Phase 3. Subchronic Exposures.
Abstract
Inhalation exposures were performed twice per week, for 13 weeks, to determine whether there was any potential toxicity to rats of comparatively low concentrations of a condensation aerosol from diesel fuel. Animals were divided into 4 groups (24 per sex in each group) and exposed to aerosol concentrations of 0, 0.25, 0.75 and 1.50 mg diesel fuel aerosol/L for 4 hours per day. A fifth group (12 per sex) was used as vivarium controls. Body weight and food consumption were measured weekly for duration of the exposure and also during a two month recovery period. Changes in breathing frequency and the response of animals to a loud sharp sound (startle response) were measured in selected animals prior to the start of the exposures, at various time points during the thirteen week exposure period, and at monthly intervals during the recovery period. Assays were performed on selected animals at the end of the exposure period, and again after the two month recovery period. Endpoints included pulmonary function tests, numbers of alveolar free cells, clinical chemistry, hematology, organ weights and histopathology. No mortalities were recorded during the exposure or recovery periods. Originator-supplied keywords include: Aerosol, Alevolar macrophage, Body weight, Breathing frequency, Clinical chemistry, Diesel fuel, Exposure concentration, Food consumption, Hematology, Histopathology, Inhalation, Organ weight, Pulmonary free cells, Pulmonary function, Rats, Startle, Response, Subchronic, Toxicity.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1984
- Accession Number
- ADA150100
Entities
People
- R. Griesemer
- R. Schmoyer
- S. Lock
- W. Dalbey
Organizations
- Oak Ridge National Laboratory