Evaluation of Antimony Thioantimonate in Three in Vitro Short-Term Assays.
Abstract
A metal compound, antimony thioantimonate, was evaluated in three mammalian cell in vitro short-term assays to determine its potential biological activity. The assays conducted were the Chinese hamster ovary (CHO) cell gene mutation assay, in the absence and presence of an Aroclor 1254-induced rat liver S9 fraction, the CHO/chromosome aberrations assay in the absence and presence of an Aroclor 1254-induced rat liver S9 fraction, and the BALB/c-3T3 neoplastic transformation assay. Under the conditions of the assays, antimony thioantimonate produced a clastogenic effect in the CHO/chromosome aberrations assay. The clastogenic response was enhanced in the presence of an exogenuous metabolic activation system. The test compound produced no mutagenic activity in the CHO cells with or without an exogenous metabolic activation supplement and it produced no transformation activity in the BALB/c-3T3 neoplastic transformation assay.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 14, 1984
- Accession Number
- ADA150348
Entities
People
- A. S. Tu
- A. Sivak
Organizations
- Arthur D. Little