Chiral Polymers.
Abstract
Chiral vinyl monomers containing the oxazoline units, 2-vinyl-4-methoxy-methyl- and 4-hydroxymethyl-5-phenyloxazoline as well as a chiral oxazoline monomer bearing an acrylate polymerizable group were synthesized. In addition, an acrylamide monomer containing a chiral 1,3-dioxane unit as well as both racemic and (R)-alpha-methylene-gamma-methyl-gamma-butyrolactone were synthesized. The vinyloxazoline,, 2-vinyl-4-methoxymethyl-5-phenyloxazoline was copolymerized with styrene and divinylbenzene by suspension techniques to give polymer beads approx. 50 microns in diameter. The oxazoline monomer containing the polymerizable acrylate group and the acrylamide monomer containing the dioxolane unit also were copolymerized with styrene and divinyl benzene to give cross-linked polymer beads, approx. 50 microns in diameter. Racemic and chiral alpha-methylene-gamma-methyl-gamma-bu tyrolactone were homopolymerized by radical, anionic, and group transfer methods. Chiral lactone gave isotactic polymer, regardless of the method of polymerization. The styrene-bead copolymers were packed in HPLC columns, but none were especially effective in separating enantiomers in a racemic mixture. The chiral butyrolactone polymer was coated on silica, but this material did not effect resolution of racemic mixtures in an HPLC column. Originator furnished keywords are: Vinyl oxazolines, Alpha-methylene-gamma-methyl-gamma-butyrolactone, Chromatography, Copolymer beads, Chiral Monomers, HPLC, Chiral copolymers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1984
- Accession Number
- ADA150366
Entities
People
- A. I. Meyers
- J. K. Stille
Organizations
- Colorado State University