Acute Effects of Anticholinesterase Agents on Pupillary Function.

Abstract

The effect of anticholinesterase agents on pupillary function and parameters of cholinergic activity were investigated both in vitro and in vivo following topical administration. The study describes changes in three different aspects of cholinergic function: (1) uptake of choline, (2) release of acetylcholine and (3) AChE activity and pupil size. Our results are consistent with the concept of existence of a presynaptic muscarinic autoreceptor which is affected (DFP directly or through acetylcholine). DFP exerts multiple effects on various cholinergic parameters.

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Document Details

Document Type
Technical Report
Publication Date
Mar 15, 1984
Accession Number
ADA150616

Entities

People

  • E. Giacobini

Organizations

  • Southern Illinois University School of Medicine

Tags

DTIC Thesaurus Topics

  • Air Force
  • Animals
  • Biochemistry
  • Brain
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Cholinergic Nerves
  • Enzyme Inhibitors
  • Nervous System
  • Neurons
  • New York
  • Parkinson'S Disease
  • Peripheral Nervous System
  • Pharmacology
  • Rodents
  • Synapses

Readers

  • Neurotoxicology
  • Theoretical Analysis.
  • Vision Science/Vision Psychology/Cognitive Neuroscience.