Acute Effects of Anticholinesterase Agents on Pupillary Function.

Abstract

Three main directions of our research have been pursued. First, we have accumulated new pharmacological evidence for a mechanism of acetylcholine release related to a muscarinic autoreceptor present in the rat iris. Secondly, we have continued our study drug effect on the release of acetylcholine, adding a new group of drugs, the aminopyridines, which enhance calcium ions influx into the neuron. Finally, we have studied the effect of aging on pupillary function and ACh metabolism. These three lines of work have each produced novel and intriguing results which are summarized in the following section. The results described in this report have been communicated at several national and international meetings. The abstracts of the communications are attached to the progress report.

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Document Details

Document Type
Technical Report
Publication Date
Sep 15, 1984
Accession Number
ADA150815

Entities

People

  • E. Giacobini

Organizations

  • Southern Illinois University School of Medicine

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Abstracts
  • Acetylcholinesterases
  • Alkaloids
  • Amines
  • Chemistry
  • Cholinergic Nerves
  • Classification
  • Enzyme Inhibitors
  • Illinois
  • Inhibitors
  • Kinetics
  • Nerve Fibers
  • Peripheral Nervous System
  • Rodents
  • Schools
  • Security
  • Synapses

Readers

  • Neuroscience
  • Neurotoxicology
  • Technical Research and Report Writing.