Study of Toxic and Antigenic Structures of Botulinum Neurotoxins
Abstract
The immunologically distinct botulinum neurotoxin (NT) types A, B, E, and F were defined in terms of amino acid composition (number of residues/protein molecule). The subunit heavy and light chains of type A NT were separated and their amino sequences were partially determined. Histidine residues of type A and E appear critical for toxicity but not for serological reactivity. The paralyzing effect of type B has a shorter duration of action, than type A, at the rat neuromuscular junction but less effectively antagonized by 3,4-diaminopyridine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1983
- Accession Number
- ADA151232
Entities
People
- Bibhuri R. Dasgupta
Organizations
- University of Wisconsin–Madison