Research and Development on the Modification of Stroma-Free Hemoglobin for Use as a Blood Substitute.

Abstract

Chemical modification of stroma-free hemoglobin (SFH) using a series of ribose phosphates has been achieved. The P50 is 50-70% improved and the intravascular retention time increased by two to eight times (species dependent). The dial modified SFH has normal oxygen carrying capacity and maximally altered energetics. It is stable at 4 C liquid storage and maximum met-Hb is 4.5%. Details of the reactions indicate a significant yield 90% can be obtained by iteration of the reaction steps. Extensive pruification is not needed. Keywords include: Blood substitutes; strome-free hemoglobin; ribose phosphate-dial; hexandial monophosphate; oxy-hemoglobin dissociation; retention time; hemoglobin modification.

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Document Details

Document Type
Technical Report
Publication Date
Apr 14, 1984
Accession Number
ADA151674

Entities

People

  • A. G. Greenburg
  • P. W. Maffuid

Organizations

  • University of California, San Diego

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Aldehydes
  • Blood
  • Blood Substitutes
  • Chemical Synthesis
  • Chemistry
  • Detectors
  • Fluids
  • Hemoglobin
  • Laboratory Animals
  • Liquid Chromatography
  • Materials
  • Measurement
  • Nucleotides
  • Organic Chemistry
  • Pyridoxal Phosphate

Readers

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  • Mathematics or Statistics
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